Fig. 5.

(a) Detection of protein binding to ABC assemblies of DNA-modified AuNPs via SERS (left); averaged spectra of labelled proteins: streptavidin (black), TBP (blue), and M.HhaI (red) with cognate-DNA (solid lines) and noncognate-DNA (x5 signal, dotted lines). Adapted with permission from Ref. [62] (b) SERS spectra of transplatin bound to 30 bp dsDNA SN5. (i) before, (ii) immediately following, and (iii) after overnight incubation with transplatin. Adapted with permission from Ref. [63] (c) Applying SERS to reveal covalent binding of cisplatin, intercalation of methylene blue and formation of T-Hg²-T base pairs with dsDNA. Adapted with permission from Ref. [64]. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)