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Protein thermal shift of selected compounds against NDM-1.[a]
| Compound | ∆Tm (°C) | Compound | ∆Tm (°C) |
|---|---|---|---|
| l-Captopril | 4.61±0.07 | DPA | −14.5±0.2 |
| IDA | 4.39±0.04 | 1 | 1.9±0.2 |
| 21h | 4.43±0.07 | 21i | 3.4±0.3 |
| 23a | 3.1±0.1 | 23b | 1.6±0.4 |
| 23c | 5.2±0.1 | 23d | 3.4±0.2 |
| 23e | 1.7±0.2 | 23f | 1.5±0.1 |
| 23g | 3.0±0.3 | 23h | 4.2±0.2 |
Values are the average of eight replicates with standard deviations shown. Native NDM-1 was observed to melt at TM = 55.95±0.06 °C.
