Table 6.
Summary of the native ESI-MS experimental results for NDM-1.[a]
| Sample | NDM-1 + Inhibitor Complex Mass (Da) | Peak Charge (+) | Predicted Peak (m/z) | Observed Peak (m/z) | Complex |
|---|---|---|---|---|---|
| NDM-1 | 25,385 | 9 | 2,821 | 2,822 | 2Zn: NDM-1 |
| 25,385 | 10 | 2,539 | 2,540 | 2Zn: NDM-1 | |
| NDM-1 + DPA | 25,255 | 9 | 2,807 | 2,807 | 0Zn: NDM-1 |
| 25,320 | 9 | 2,814 | 2,814 | 1Zn: NDM-1 | |
| 25,385 | 9 | 2,821 | 2,821 | 2Zn: NDM-1 | |
| NDM-1 + 1 | 25,532 | 9 | 2,838 | 2,837 | 2Zn: NDM-1:1 |
| NDM-1 + 23c | 25,628 | 9 | 2,848 | 2,850 | 2Zn: NDM-1:23c |
| 8 | 3,204 | 3,210 | 2Zn: NDM-1:23c | ||
| NDM-1 + 23d | 25,612 | 9 | 2,847 | 2,846 | 2Zn: NDM-1:23d |
| 8 | 3,202 | 3,202 | 2Zn: NDM-1:23d | ||
| NDM-1 + 23e | 25,628 | 9 | 2,848 | 2,847 | 2Zn: NDM-1:23e |
| 8 | 3,204 | 3,205 | 2Zn: NDM-1:23e | ||
| NDM-1 + 23f | 25,612 | 9 | 2,847 | 2,848 | 2Zn: NDM-1:23f |
| 8 | 3,202 | 3,202 | 2Zn: NDM-1:23f |
[a]
Percent error was calculated by subtracting the expected peak value from the actual peak value, dividing by the expected peak value and multiplying by 100 and all observed to be <0.2%.