Table 1.

Differences in Immunophenotype Between Active and Suppressive Cells for Cervical Cancer

	Immune Active Cell	Immune Suppressive Cell
T cell	Th1 secretes anti-tumor factors IL-2, IFN-γ; CTL increases.	Th2 via IL-10, Th17 via IL-17, Tregs via IL-12, IL-21, abundant immunosuppressive cytokines infiltrate.
B cell	Unknown	B cells may promote tumor progression.
NK cell	CD56 NK cells increase IFN- γ, TNF-α.	/
DC	DCs Elicit Th1 and CTL response	/
Macrophage	M1 secretes TNF-α, kills pathogens and promotes Th1 response.	TAM refers to M2, higher immune infiltrates including TGF-ß, VEGF and PD-L1 to elicit tumor promotion and Th2 response.
EOS	/	Increased EOS are regulated by cytokines as IL-3, IL-5 and GM-CSF, correlated with prognosis.
MDSC	/	MDSC and IL-10 attenuate tumor growth and inhibit IL-6.

Notes: In this review, immune cells are divided into immune active and suppressive cells to better demonstrate CC’s immune microenvironment. That is to say, immune active cells tend to fight against cancer development while immune suppressive cells exert pro-inflammatory or cancer progression role.