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. 2020 Aug 12;13:7985–7995. doi: 10.2147/OTT.S249667

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© 2020 Guo et al.

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COL1A1 promotes invasion and migration of GC cells via activating the TGF-β signaling pathway. (A) GSEA pathway enrichment analysis revealed that high expression of COL1A1 was associated with TGF-β signaling pathway; (B) The expression of COL1A1 in GC cells was detected by qRT-PCR; (C, D) The (C) Invasion and (D) Migration abilities of cells in each group were detected by Transwell and wound healing assays; (E, F) The protein expression of (E) COL1A1 and TGF-β signaling pathway-related proteins TGFβR1, TGFβR2 and (F) Nuclear proteins pSMAD3 and SMAD3 were detected by WB. *P<0.05.