Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Aug 10;13:7921–7932. doi: 10.2147/OTT.S256161

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 Zang et al.

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).

PMC Copyright notice

miR-137-3p directly targets JNK3. (A) miR-137-3p-binding sites located on the 3ʹUTR of JNK3 mRNA and the wild-type or mutant site of JNK3 3ʹUTR were cloned into the pmirGLO plasmid. (B) and (C) miR-137-3p mimics or scramble control and wild-type or mutant JNK3 3ʹUTR were cotransfected into PC-3 or DU145 cells. miR-137-3p reduced luciferase activities in prostate cancer cells transfected with the wild-type 3ʹUTR but did not alter luciferase activities in cells transfected with the mutant JNK3 3ʹUTR. (D) Western blotting was performed after transfecting cells with miR-137-3p mimics or control, and (E) JNK3 protein levels were detected in xenograft samples. **p<0.01 compared to the corresponding controls.