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. 2020 Aug 14;12:7277–7289. doi: 10.2147/CMAR.S257311

Figure 1.

Figure 1

NEAT1 expression is enhanced in cisplatin-resistant ovarian cancer tissues and cells. (A) The expression of NEAT1 was measured in ovarian cancer tissues and para-tumor tissues (n=37) by qRT-PCR. (B) The level of NEAT1 was detected in cisplatin-sensitive (n=18) and cisplatin-resistant tissues (n=19) by qRT-PCR. (C) The expression of NEAT1 was examined in cisplatin-sensitive ovarian cancer cells (A2780 and SKOV3) and cisplatin-resistant cells (A2780/DDP and SKOV3/DDP) by qRT-PCR. (D and E) The cell viability and IC50 of cisplatin (DDP) were analyzed in A2780, A2780/DDP, SKOV3 and SKOV3/DDP cells after treatment of different concentrations of cisplatin for 48 h by MTT. The difference was compared with the indicated control group and analyzed via Student’s t-test or ANOVA followed via Tukey post hoc test. *P<0.05.