. 2020 May 15;13(5):721–731. doi: 10.1038/s41385-020-0294-6

Table 1.

Intestinal human and murine innate-like subset representation, their TCR repertoire and receptor expression profile.

T-IEL type	TCR ligands	Receptors expressed
Mouse
Innate-like TCRγδ CD8αα	Nonclassical MHC; Btnl1/Btnl6 (Vγ7)	NKG2D^a; CD160^b; CD100^b; Ly49E^b; CD200R^b; 2B4^b; JAML^b; LAG-3^b; TIGIT^b; Gp49^b
Innate-like TCRαβ CD8αα	Classical and nonclassical MHC class I and II (cross-reactive)	NKG2D^a; CD160^b; CD100^b; Ly49 family^b; CD200R^b; CD94/NKG2^a,b; 2B4^b; JAML^b; LAG-3^b; TIGIT^b; Gp49^b
Induced TCRαβ CD8αβ or CD4	MHC class I or II	CD160^b; CD100^b; CD200R^b; 2B4^b; JAML^b; CTLA-4^b
Human
Innate-like TCRγδ	Nonclassical MHC; BTNL 3/8 (Vγ4)	NKp46^b
Innate-like TCRαβ	unknown	unknown
Induced TCRαβ CD8αβ or CD4	MHC class I or II	NKG2D^a; CD94/NKG2^a,b; Nkp46^a

T-IEL subset composition differ from humans to mice. In humans, induced TCRαβ CD8αβ T-IEL are predominant while in mice, the majority of T-IEL is composed of innate-like T-IEL (TCRαβ CD8αα and TCRγδ CD8αα). In addition to their TCR, human and murine T-IEL express numerous activating and inhibitory receptors, suggesting alternative modes of activation.

^aExpression induced by inflammatory signals or in the context of disease.

^bConstitutively expressed.