Table 1.
Lung histopathology analysis of Mtb-infected mice.
| Low dose | High dose | |||||||
|---|---|---|---|---|---|---|---|---|
| day 30 | day 60 | Moribund Gcnt1−/− (3) | day 27 | |||||
| Score | B6 (12) | Gcnt1−/− (13) | B6 (7) | Gcnt1−/− (6) | B6 (7) | Gcnt1−/− (10) | ||
| Perivascular lymphocytes | 0 | |||||||
| 1 | 8.30 | |||||||
| 2 | 91.7 | 23.1 | 28.6 | 50.0 | 28.6 | 16.7 | ||
| 3 | 76.9 | 71.4 | 100 | 50.0 | 71.4 | 83.3 | ||
| Peribronchiolar lymphocytes | 0 | |||||||
| 1 | 44.4 | 55.6 | 57.1 | 33.3 | 14.3 | |||
| 2 | 55.6 | 33.3 | 42.9 | 50 | 50.0 | 42.9 | 66.7 | |
| 3 | 11.1 | 16.7 | 50.0 | 42.9 | 33.3 | |||
| Bronchiolar debris | 0 | 70.0 | 66.7 | 42.9 | 50 | 14.3 | ||
| 1 | 30.0 | 22.2 | 57.1 | 33.3 | 57.1 | 10.0 | ||
| 2 | 11.1 | 16.7 | 66.7 | 14.3 | 20.0 | |||
| 3 | 33.3 | 14.3 | 70.0 | |||||
| Intra-alveolar necrotic debris | 0 | |||||||
| 1 | 16.7 | 46.2 | 57.1 | 16.7 | 33.3 | |||
| 2 | 66.7 | 30.8 | 14.3 | 50 | 66.7 | 28.6 | ||
| 3 | 16.7 | 23.1 | 28.6 | 33.3 | 71.4 | 100 | ||
| Necrosis | 0 | 100 | 92.3 | 100 | 100 | 42.9 | ||
| 1 | 28.6 | 10.0 | ||||||
| 2 | 7.70 | 28.6 | 10.0 | |||||
| 3 | 100 | 20.0 | ||||||
| 4 | 60.0 | |||||||
Lung H&E sections of C57BL/6 (B6) or Gcnt1−/− infected animals were assessed and scored for the indicated histopathological features. Indicated is the % of animals with a certain score within the indicated experimental group. Indicated in brackets is the number of animals analysed per group.