TABLE 1.
Baseline clinical characteristics of lipoprotein glomerulopathy patients
| Parameters | Subjects | |||||||
|---|---|---|---|---|---|---|---|---|
| F171101‐II4 | F17A0528‐II2 | F15A1307‐II1 | F15A1558‐II1 | F98034‐III1 | F16A0702‐II2 | F16A1578‐II1 | F19A0312‐II4 | |
| Age (year) | 42 | 16 | 30 | 50 | 38 | 22 | 28 | 50 |
| Gender | M | M | F | M | F | M | M | M |
| Family history | Y | Y | Y | N | Y | Y | N | N |
| MAP (mmHg) | 91 | 116 | 84 | 117 | 117 | 141 | 141 | 106 |
| Alb (g/L) | 33.6 | 20.0 | 34.0 | 20.0 | 22.3 | 21.0 | 19.1 | 31.2 |
| Hb (g/L) | 121 | 106 | 117 | 137 | 101 | 115 | 117 | NA |
| Upro (g/24 hr) | 1.5 | 5.1 | 1.5 | 5.0 | 10.5 | 10.0 | 8.8 | 5.7 |
| eGFR (ml/min per 1.73 m2) | 56.2 | 110.8 | 101.2 | 84.5 | 93.4 | 98.5 | 71.9 | 51.9 |
| TG (mmol/L) | 3.0 | 2.7 | 1.5 | 3.0 | 3.7 | 1.9 | 2.1 | 4.3 |
| TC (mmol/L) | 7.6 | 6.4 | 3.4 | 7.8 | 5.8 | 3.5 | 9.9 | 5.2 |
| apoE (mg/dl) | 4.5 | 6.4 | 3.6 | 6.6 | NA | 3.6 | 4.1 | NA |
| APOE mutation | Kyoto | Kyoto | Kyoto | Kyoto | Kyoto | Osaka | Osaka | Chicago |
| APOE genotype | ε3/ε3 | ε3/ε4 | ε3/ε3 | ε3/ε4 | ε3/ε3 | ε3/ε3 | ε3/ε4 | ε3/ε3 |
| Pathology a | ||||||||
| Global sclerosis | 3 | 1 | 1 | 1 | 0 | 2 | 2 | 0 |
| Segmental sclerosis | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
| Interstitial fibrosis | 2 | 1 | 0 | 1 | 1 | 1 | 2 | 1 |
| Interstitial inflammatory cell infiltration | 2 | 1 | 0 | 1 | 0 | 1 | 2 | 1 |
| Tubular atrophy | 2 | 1 | 0 | 1 | 1 | 1 | 2 | 0 |
| Vascular lesion | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
The standards of pathology grade were as follows:
Global sclerosis was defined as sclerosis involving the entire glomerular tuft. Global sclerosis was scored by the percentage of glomeruli with these lesions: 0, 0%; 1, <10%; 2, 10%–24%; 3, ≥25%.
Segmental sclerosis was defined as tufts involved with sclerosis other than global sclerosis. Segmental sclerosis was scored as follows: 0, absent; 1, present.
The severity of interstitial fibrosis, interstitial inflammatory cell infiltration and tubular atrophy are defined as follows: 0, 0% area involved; 1, <10%; 2, 10%–24%; 3, ≥25%.
The vascular lesion was defined by arterial hyaline change and vascular wall thickening: for either, definitions were 0, absent, or 1, present.
Abbreviations: Alb, albumin; apoE, apolipoprotein E; Chicago, APOE‐Chicago (p.R147P); EPI‐eGFR, estimated glomerular filtration rate using EPI; F, female; Hb, hemoglobin; Kyoto, APOE‐Kyoto (p.R25C); M, male; MAP, mean arterial pressure; N, No; NA, not available. All the parameters in this table were obtained at time of kidney biopsy; Osaka, APOE‐Osaka/Kurashiki (p.R158P); TC, total cholesterol; TG, triglyceride; Upro, urine protein; Y, Yes.