TABLE 3.
SNPs genetic models and analyses of the association between SNPs and AMS
| SNP No. | Genotype | Total | Non‐AMS (%) | AMS (%) | Β | SE | χ 2 | p | OR (95% CI) |
|---|---|---|---|---|---|---|---|---|---|
| rs1008438 | C | 128 (39.02) | 86 (45.26) | 42 (30.43) | |||||
| A | 200 (60.98) | 104 (54.74) | 96 (69.57) | 7.39 | .01* | ||||
| CC | 29 (17.68) | 20 (21.05) | 9 (13.04) | −1.01 | 0.47 | 4.61 | .03 | 0.36 (0.14, 0.92) | |
| CA | 70 (42.68) | 46 (48.42) | 24 (34.78) | −0.87 | 0.35 | 5.98 | .01 | 0.42 (0.21, 0.84) | |
| AA | 65 (39.63) | 29 (30.53) | 36 (52.17) | — | — | — | — | — | |
| CC + CA | 99 (60.37) | 66 (69.47) | 33 (47.83) | −0.91 | 0.33 | 7.68 | .01 | 0.40 (0.21, 0.77) | |
| AA | 65 (39.63) | 29 (30.53) | 36 (52.17) | — | — | — | — | ||
| CC | 29 (17.68) | 20 (21.05) | 9 (13.04) | 0.58 | 0.44 | 1.73 | .19 | 0.56 (0.24, 1.33) | |
| CA + AA | 135 (82.32) | 75 (78.95) | 60 (86.96) | — | — | — | — | — | |
| rs150877473 | G | 9 (2.74) | 5 (2.63) | 4 (2.90) | |||||
| C | 319 (97.26) | 185 (97.37) | 134 (97.10) | 0.02 | .88 | ||||
| GG | 0 (0.00) | 0 | 0 | — | — | — | — | — | |
| GC | 9 (5.49) | 5 (5.26) | 4 (5.80) | 0.10 | 0.69 | 0.02 | .88 | 1.11 (0.29, 4.29) | |
| CC | 155 (94.51) | 90 (94.74) | 65 (94.20) | — | — | — | — | — | |
| GG + GC | 9 (5.49) | 5 (5.26) | 4 (5.80) | 0.10 | 0.69 | 0.02 | .88 | 1.11 (0.29, 4.29) | |
| CC | 155 (94.51) | 90 (94.74) | 65 (94.20) | — | — | — | — | — | |
| GG | 0 (0.00) | 0 | 0 | — | — | — | — | — | |
| GC + CC | 164 (100.0) | 95 (100.00) | 69 (100.00) | — | — | — | — | — | |
| rs1799983 | T | 38 (11.59) | 21 (11.05) | 17 (12.32) | |||||
| G | 290 (88.41) | 169 (88.95) | 121 (87.68) | 0.13 | .72 | ||||
| TT | 3 (1.83) | 1 (1.05) | 2 (2.90) | 1.02 | 1.24 | 0.68 | .41 | 2.78 (0.25, 31.42) | |
| GT | 32 (19.51) | 19 (20.00) | 13 (18.84) | −0.05 | 0.40 | 0.02 | .90 | 0.95 (0.43, 2.09) | |
| GG | 129 (78.66) | 75 (78.95) | 54 (78.26) | — | — | — | — | — | |
| TT + GT | 35 (21.34) | 20 (21.05) | 15 (21.74) | 0.04 | 0.39 | 0.01 | .92 | 1.04 (0.49, 2.22) | |
| GG | 129 (78.66) | 75 (78.95) | 54 (78.26) | — | — | — | — | — | |
| TT | 3 (1.83) | 1 (1.05) | 2 (2.90) | −1.03 | 1.24 | 0.70 | .40 | 2.81 (0.25, 31.58) | |
| GT + GG | 161 (98.17) | 94 (98.95) | 67 (97.10) | — | — | — | — | — | |
| rs2153364 | A | 169 (51.84) | 104 (55.32) | 65 (47.10) | |||||
| G | 157 (48.16) | 84 (44.68) | 73 (52.90) | 2.15 | .14 | ||||
| AA | 40 (24.39) | 27 (28.42) | 13 (18.84) | −0.73 | 0.48 | 2.31 | .13 | 0.48 (0.19, 1.24) | |
| AG | 89 (54.27) | 50 (52.63) | 39 (56.52) | −0.25 | 0.40 | 0.38 | .54 | 0.78 (0.35, 1.72) | |
| GG | 35 (21.34) | 18 (18.95) | 17 (24.64) | — | — | — | — | — | |
| AA + AG | 129 (78.66) | 77 (81.05) | 52 (75.36) | −0.39 | 0.39 | 1.03 | .31 | 0.68 (0.32, 1.44) | |
| GG | 35 (21.34) | 18 (18.95) | 17 (24.64) | — | — | — | — | — | |
| AA | 40 (24.39) | 27 (28.42) | 13 (18.84) | 0.55 | 0.38 | 2.07 | .15 | 0.58 (0.27 ,1.22) | |
| AG + GG | 124 (75.61) | 68 (71.58) | 56 (81.16) | — | — | — | — | — | |
| rs3025039 | T | 52 (15.95) | 29 (15.43) | 23 (16.67) | |||||
| C | 274 (84.05) | 159 (84.57) | 115 (83.33) | 0.09 | .76 | ||||
| TT | 6 (3.66) | 4 (4.21) | 2 (2.90) | −0.33 | 0.89 | 0.14 | .71 | 0.72 (0.13, 4.08) | |
| CT | 40 (24.39) | 21 (22.11) | 19 (27.54) | 0.26 | 0.37 | 0.51 | .48 | 1.30 (0.63 ,2.68) | |
| CC | 118 (71.95) | 70 (73.68) | 48 (69.57) | — | — | — | — | — | |
| TT + CT | 46 (28.05) | 25 (26.32) | 21 (30.43) | 0.19 | 0.35 | 0.29 | .59 | 1.21 (0.61,2.40) | |
| CC | 118 (71.95) | 70 (73.68) | 48 (69.57) | — | — | — | — | — | |
| TT | 6 (3.68) | 4 (4.21) | 2 (2.90) | 0.40 | 0.88 | 0.20 | .65 | 0.67 (0.12, 3.78) | |
| CT + CC | 158 (96.34) | 91 (95.79) | 67 (97.10) | — | — | — | — | — |
Abbreviations: AMS, acute mountain sickness; CI, confidence intervals; OR, Odds ratio; SNP, single nucleotide polymorphism.
*
Indicates statistically significant after the false discovery rate (FDR) correction.