Table 1.
Characteristics of participants, overall and by IL-6 category (N=289)
| Description | Overall (N=289) | 1st IL-6 Tertile (N=96) | 2nd IL-6 Tertile (N=97) | 3rd IL-6 Tertile (N=96) | p-value |
|---|---|---|---|---|---|
| Age, years | 78.3 (5.4) | 78.1 (5.1) | 77.7 (5.6) | 79.1 (5.4) | 0.178 |
| Male | 152 (52.6) | 49 (51.0) | 42 (43.3) | 61 (63.5) | 0.018 |
| Race White | 225 (77.9) | 79 (82.3) | 74 (76.3) | 72 (75.0) | 0.411 |
| BMI, kg/m2 | 31.4 (5.7) | 30.8 (5.1) | 32.1 (6.2) | 31.4 (5.7) | 0.321 |
| Weight, kg | 87.0 (17.8) | 86.2 (16.7) | 87.2 (18.6) | 87.7 (18.1) | 0.841 |
| Waist Circumference, cm | 107.3 (14.9) | 107.4 (15.3) | 106.3 (15.1) | 108.3 (14.2) | 0.656 |
| High BP self-report | 200 (69.2) | 58 (60.4) | 74 (76.3) | 68 (70.8) | 0.053 |
| Type 2 Diabetes | 68 (23.5) | 21 (21.9) | 26 (26.8) | 21 (21.9) | 0.647 |
| Ischemic Heart Disease | 38 (13.1) | 10 (10.4) | 13 (13.4) | 15 (15.6) | 0.563 |
| Stroke | 13 (4.5) | 7 (7.3) | 2 (2.1) | 4 (4.2) | 0.211 |
| Cancer History | 109 (37.7) | 40 (41.7) | 31 (32.0) | 38 (39.6) | 0.341 |
| Pulmonary Disease | 6 (2.1) | 2 (2.1) | 2 (2.1) | 2 (2.1) | 0.999 |
| Congestive Heart Failure | 8 (2.8) | 2 (2.1) | 2 (2.1) | 4 (4.2) | 0.593 |
| 2 or more comorbidities | 138 (47.8) | 44 (45.8) | 47 (48.5) | 47 (49.0) | 0.897 |
| Former Smoker | 151 (52.8) | 50 (52.6) | 47 (49.5) | 54 (56.3) | 0.644 |
| IL-6, pg/mL | 4.77 (3.19) | 3.03 (0.27) | 3.98 (0.32) | 7.32 (4.52) | <.0001 |
| Time engaged in physical activity, min | 327.6 (647.3) | 354.3 (540.5) | 344.1 (909.4) | 284.2 (373.4) | 0.721 |
| Handgrip Strength, kg | 26.5 (8.8) | 26.6 (9.5) | 26.0 (8.5) | 27.0 (8.3) | 0.736 |
| Knee Extensor Strength 60°/sec, Nm | 82.4 (32.9) | 87.6 (33.2) | 81.5 (32.7) | 77.9 (32.5) | 0.154 |
| Knee Extensor Strength 180°/sec, Nm | 55.9 (21.4) | 58.0 (22.1) | 54.8 (21.7) | 54.8 (20.5) | 0.541 |
| Knee Flexor Strength 60°/sec, Nm | 43.4 (17.0) | 44.8 (16.2) | 43.7 (17.8) | 41.7 (17.1) | 0.505 |
| Knee Flexor Strength 180°/sec, Nm | 38.5 (17.1) | 39.4 (18.2) | 37.0 (17.0) | 38.9 (16.1) | 0.635 |
| Gait Speed 4 m walk, m/s | 0.805 (0.120) | 0.806 (0.133) | 0.798 (0.121) | 0.810 (0.106) | 0.782 |
| Gait Speed 400 m walk, m/s | 0.826 (0.165) | 0.850 (0.175) | 0.825 (0.168) | 0.803 (0.148) | 0.137 |
| SPPB total score | 8.7 (2.1) | 8.8 (2.1) | 8.3 (2.1) | 8.8 (2.0) | 0.186 |
| SPPB - Balance score | 3.0 (1.1) | 3.0 (1.1) | 2.8 (1.1) | 3.1 (1.1) | 0.234 |
| SPPB - Chair Rise score | 2.3 (1.3) | 2.5 (1.2) | 2.2 (1.4) | 2.3 (1.2) | 0.276 |
| SPPB - 4-meter gait score | 3.4 (0.7) | 3.4 (0.7) | 3.3 (0.7) | 3.4 (0.7) | 0.959 |
| Lipid Lowering Drugs | 176 (60.9) | 56 (58.3) | 61 (62.9) | 59 (61.5) | 0.803 |
| RAS Inhibitors | 127 (43.9) | 32 (33.3) | 48 (49.5) | 47 (49.0) | 0.037 |
| Anti-inflammatory Drugs | 209 (72.3) | 64 (66.7) | 75 (77.3) | 70 (72.9) | 0.251 |
All data are Mean (SD) or Count (%); IL-6 = Interleukin-6; BMI = body mass index; BP = blood pressure; SPPB = Short Physical Performance Battery; RAS = renin angiotensin system