Table 2.

Adjusted associations between muscle strength and physical performance and log-transformed IL-6

Variable	Model*	Log-IL6 Partial correlation	p-value
SPPB total score	1	−0.03	0.668
	2	0.00	0.998
	3	−0.01	0.861
SPPB - Balance score	1	0.00	0.936
	2	0.00	0.943
	3	0.00	0.954
SPPB - Chair Rise score	1	−0.04	0.548
	2	−0.01	0.891
	3	−0.02	0.724
SPPB - 4-meter gait score	1	−0.02	0.757
	2	0.01	0.899
	3	0.00	0.981
Handgrip Strength, kg	1	−0.03	0.660
	2	−0.03	0.605
	3	−0.03	0.680
Knee Extensor Strength 60°/sec, Nm	1	−0.18	0.004
	2	−0.19	0.002
	3	−0.20,	0.002
Knee Extensor Strength 180°/sec, Nm	1	−0.11	0.087
	2	−0.1	0.034
	3	−0.1	0.037
Knee Flexor Strength 60°/sec, Nm	1	−0.14	0.024
	2	−0.15	0.023
	3	−0.15	0.021
Knee Flexor Strength 180°/sec, Nm	1	−0.04	0.539
	2	−0.05	0.464
	3	−0.05	0.488
Gait Speed 4 m walk, m/s	1	0.02	0.679
	2	0.04	0.539
	3	0.04	0.560
Gait Speed 400 m walk, m/s	1	−0.12	0.038
	2	−0.10	0.083
	3	−0.1	0.064

IL-6 = Interleukin-6; SPPB = Short Physical Performance Battery

^*Model 1: values adjusted for age at randomization and gender; Model 2: values adjusted for model 1 covariates, race (non-hispanic white vs. minority), body mass index, former smoker status, and having ≥ 2 comorbidities; Model 3: values adjusted for model 2 covariates, use of lipid-lowering drugs, anti-inflammatory drugs, and RAS inhibitors.