Table 3.
Least-squared means of muscle strength and physical performance values across IL-6 tertiles
| Variable | Model* | 1st Tertile IL-6 | 2nd Tertile IL-6 | 3rd Tertile IL-6 | p-value |
|---|---|---|---|---|---|
| SPPB total score | 1 | 8.8 (8.4, 9.2) | 8.3 (7.9, 8.7) | 8.8 (8.3, 9.2) | 0.198 |
| 2 | 8.7 (8.2, 9.2) | 8.3 (7.8, 8.8) | 8.8 (8.3, 9.3) | 0.206 | |
| 3 | 8.7 (8.2, 9.2) | 8.2 (7.7, 8.7) | 8.7 (8.2, 9.2) | 0.154 | |
| SPPB - Balance score | 1 | 3.0 (2.7, 3.2) | 2.8 (2.5, 3.0) | 3.1 (2.9, 3.3) | 0.086 |
| 2 | 3.0 (2.7, 3.2) | 2.7 (2.5, 3.0) | 3.1 (2.8, 3.4) | 0.088 | |
| 3 | 3.0 (2.7, 3.3) | 2.7 (2.4, 3.0) | 3.1 (2.8, 3.4) | 0.067 | |
| SPPB - Chair Rise score | 1 | 2.5 (2.2, 2.7) | 2.2 (2.0, 2.5) | 2.3 (2.0, 2.6) | 0.359 |
| 2 | 2.6 (2.2, 2.9) | 2.3 (2.0, 2.6) | 2.4 (2.1, 2.7) | 0.460 | |
| 3 | 2.5 (2.2, 2.8) | 2.3 (2.0, 2.6) | 2.4 (2.1, 2.7) | 0.436 | |
| SPPB - 4-meter gait score | 1 | 3.4 (3.2, 3.5) | 3.3 (3.2, 3.5) | 3.3 (3.2, 3.5) | 0.980 |
| 2 | 3.2 (3.0, 3.4) | 3.2 (3.0, 3.4) | 3.2 (3.1, 3.4) | 0.949 | |
| 3 | 3.2 (3.0, 3.4) | 3.2 (3.0, 3.4) | 3.2 (3.1, 3.4) | 0.961 | |
| Handgrip Strength, kg | 1 | 26.4 (25.1, 27.7) | 26.5 (25.2, 27.9) | 25.7 (24.4, 27.0) | 0.664 |
| 2 | 27.0 (25.4, 28.6) | 27.0 (25.4, 28.5) | 26.1 (24.5, 27.6) | 0.558 | |
| 3 | 27.0 (25.4, 28.7) | 27.0 (25.4, 28.6) | 26.1 (24.5, 27.7) | 0.549 | |
| Knee Extensor Strength 60°/sec (Nm) | 1 | 86.3 (80.1, 92.5) | 81.8 (75.6, 88.0) | 73.9 (67.6, 80.3) | 0.023 |
| 2 | 89.2 (81.3, 97.0) | 84.0 (76.4, 91.7) | 75.9 (68.3, 83.5) | 0.016 | |
| 3 | 88.6 (80.7, 96.4) | 83.7 (75.8, 91.5) | 76.0 (68.4, 83.7) | 0.024 | |
| Knee Extensor Strength 180°/sec (Nm) | 1 | 57.5 (53.4, 61.6) | 55.1 (51.0, 59.2) | 52.4 (48.2, 56.5) | 0.223 |
| 2 | 59.5 (54.4, 64.6) | 56.4 (51.4, 61.4) | 53.6 (48.7, 58.5) | 0.146 | |
| 3 | 59.2 (54.1, 64.4) | 56.9 (51.8, 62.1) | 54.1 (49.1, 59.1) | 0.228 | |
| Knee Flexor Strength 60°/sec (Nm) | 1 | 44.0 (40.8, 47.1) | 43.7 (40.5, 46.8) | 39.5 (36.3, 42.7) | 0.095 |
| 2 | 42.5 (38.6, 46.4) | 41.9 (38.1, 45.8) | 37.9 (34.1, 41.7) | 0.098 | |
| 3 | 42.3 (38.4, 46.3) | 42.2 (38.3, 46.2) | 38.1 (34.3, 42.0) | 0.122 | |
| Knee Flexor Strength 180°/sec, Nm | 1 | 39.2 (35.8, 42.6) | 37.0 (33.6, 40.4) | 37.1 (33.6, 40.5) | 0.585 |
| 2 | 39.6 (35.4, 43.9) | 37.0 (32.8, 41.1) | 37.2 (33.1, 41.3) | 0.480 | |
| 3 | 39.3 (35.1, 43.5) | 37.6 (33.4, 41.9) | 37.6 (33.4, 41.7) | 0.729 | |
| Gait Speed 4 m walk, m/s | 1 | 0.804 (0.780, 0.828) | 0.799 (0.775, 0.823) | 0.805 (0.781, 0.830) | 0.923 |
| 2 | 0.796 (0.766, 0.826) | 0.792 (0.762, 0.821) | 0.800 (0.771, 0.829) | 0.895 | |
| 3 | 0.794 (0.764, 0.825) | 0.790 (0.760, 0.820) | 0.800 (0.771, 0.830) | 0.849 | |
| Gait Speed 400 m walk, m/s | 1 | 0.847 (0.815, 0.879) | 0.829 (0.796, 0.861) | 0.797 (0.764, 0.829) | 0.095 |
| 2 | 0.824 (0.785, 0.863) | 0.815 (0.777, 0.853) | 0.787 (0.749, 0.824) | 0.246 | |
| 3 | 0.820 (0.781, 0.859) | 0.810 (0.771, 0.848) | 0.784 (0.746, 0.822) | 0.284 |
All data are Mean (95% confidence interval); IL-6 = Interleukin-6; SPPB = Short Physical Performance Battery
*
Model 1: values adjusted for age at randomization and gender; Model 2: values adjusted for model 1 covariates, race (non-hispanic white vs. minority), body mass index, former smoker status, and having ≥ 2 comorbidities; Model 3: values adjusted for model 2 covariates, use of lipid-lowering drugs, anti-inflammatory drugs, and RAS inhibitors.