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. Author manuscript; available in PMC: 2021 Aug 20.
Published in final edited form as: Free Radic Biol Med. 2020 Jul 4;156:176–189. doi: 10.1016/j.freeradbiomed.2020.06.004

Figure 1.

Figure 1.

Ultrastructural changes to the RPE after chronic smoking. A. Normal morphology and ultrastructure of the RPE from a C57BL6J mouse raised in air. Apical microvilli (MV) surround photoreceptor outer segments (POS). The basolateral (BL) RPE has normal infoldings (arrowheads). A variety of ultrastructural changes are seen in the RPE from C57BL6J mice exposed to smoke for 6 months. B. The microvilli are shortened, multiple vacuoles (V) are seen within the cell body, and the basal infoldings are shortened and widened (arrowheads). C. More severe mesenchymal shape to the RPE cell with similar changes to the microvilli and basal infoldings as in (B). Undigested POS (arrows) are seen in the basal region of the cell. D. Vacuoles with membranous debris are seen. BrM, Bruch’s membrane, CC, choriocapillaris. Bar = 5 μm.