. Author manuscript; available in PMC: 2021 Sep 10.

Published in final edited form as: J Control Release. 2020 Jul 7;325:347–358. doi: 10.1016/j.jconrel.2020.06.023

Table 1.

Different oil-phase compositions used for making naltrexone- loaded PLGA microparticles.

Formulation	PLGA (g)	PLGA MW (kDa)	Naltrexone (g)	Benzyl alcohol (g)	DCM (g)	PLGA Conc. (%)(w/w)
A	1.0 × 0.625	148	1.0 × 0.3675	1.0 × 0.582	10	5.58
B	1.4 × 0.625	148	1.4 × 0.3675	1.4 × 0.582	10	7.48
C	2.0 × 0.625	148	2.0 × 0.3675	2.0 × 0.582	10	10.00
D	2.4 × 0.625	148	2.4 × 0.3675	2.4 × 0.582	10	11.63
E	2.8 × 0.625	148	2.8 × 0.3675	2.8 × 0.582	10	13.10
F	3.0 × 0.625	148	3.0 × 0.3675	3.0 × 0.582	10	13.75
G	4.0 × 0.625	148	4.0 × 0.3675	4.0 × 0.582	10	16.85
H	4.0 × 0.625	79	4.0 × 0.3675	4.0 × 0.582	10	16.85
I	4.0 × 0.625	64	4.0 × 0.3675	4.0 × 0.582	10	16.85

MW: molecular weight; DCM: dichloromethane