Table 3.
Size distribution metrics of the microparticles made with different oil-phase formulations and homogenizer speeds of 2,000 and 3,000 RPM.
| Homogenizer Speed = 2000 RPM | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Formulation | Viscosity (mPa·s) | D10 (μm) | D50 (μm) | D90 (μm) | DMax (μm) | Span | V% (<25 μm) | V% (>150 μm) | Total loss (%) |
| A | 52.6 ± 2.3 | 18.5 | 46.4 | 76.7 | 130 | 1.24 | 12.9 | 0 | 12.9 |
| B | 125.6 ± 2.3 | 18.2 | 54.8 | 94.7 | 170 | 1.39 | 12.6 | 0.15 | 12.8 |
| C | 426 ± 18.6 | 13.8 | 53.0 | 104.6 | 170 | 1.7 | 17.1 | 0.51 | 17.6 |
| D | 840.3 ± 31.0 | 10.6 | 44.9 | 97.9 | 212 | 1.9 | 23.1 | 1.01 | 24.1 |
| E | 1,442 ± 46.5 | 8.4 | 40.0 | 92.0 | 170 | 2.1 | 28.2 | 0.33 | 28.5 |
| F | 1,777 ± 93.0 | 6.2 | 36.7 | 103.9 | 250 | 2.7 | 31.8 | 3.22 | 35.0 |
| G | 4,046 ± 93.0 | 2.9 | 22.2 | 72.5 | 170 | 3.1 | 49.4 | 0.16 | 49.5 |
| H | 515.3 ± 18.6 | 11.6 | 48.6 | 105.2 | 212 | 1.9 | 20.2 | 1.34 | 21.6 |
| I | 190.7 ± 9.3 | 16.1 | 54.1 | 102.9 | 170 | 1.60 | 14.3 | 0.47 | 14.8 |
| Homogenizer Speed = 3000 RPM | |||||||||
| Formulation | Viscosity (mPa·s) | D10 (μm) | D50 (μm) | D90 (μm) | DMax (μm) | Span | V% (<25 μm) | V% (>150 μm) | Total loss (%) |
| A | 52.6 ± 2.3 | 11.2 | 34.4 | 62.1 | 106 | 1.48 | 26.4 | 0 | 26.4 |
| B | 125.6 ± 2.3 | 11.9 | 40.2 | 69.8 | 106 | 1.44 | 22.2 | 0 | 22.2 |
| C | 426 ± 18.6 | 9.6 | 40.0 | 78.7 | 130 | 1.7 | 26.6 | 0 | 26.6 |
| D | 840.3 ± 31.0 | 7.8 | 38.6 | 85.0 | 170 | 2.0 | 29.2 | 0.14 | 29.4 |
| E | 1,442 ± 46.5 | 6.0 | 36.4 | 89.3 | 170 | 2.3 | 32.1 | 0.28 | 32.3 |
| F | 1,777 ± 93.0 | 2.9 | 20.4 | 69.6 | 170 | 3.3 | 52.5 | 0.1 | 52.6 |
| G | 4,046 ± 93.0 | 2.4 | 18.8 | 69.3 | 170 | 3.5 | 53.4 | 0.15 | 53.5 |
| H | 515.3 ± 18.6 | 9.7 | 45.0 | 96.5 | 170 | 1.9 | 23.6 | 0.35 | 23.9 |
| I | 190.7 ± 9.3 | 10.5 | 39.4 | 75.6 | 130 | 1.65 | 25.9 | 0 | 25.9 |