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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Matrix Biol. 2020 Mar 21;91-92:136–151. doi: 10.1016/j.matbio.2020.03.007

Figure 2: Modeling of post-MI fibroblast signaling reproduces dynamics of post-MI collagen expression and deposition.

Figure 2:

A) Validation of the predicted timing of collagen expression post-MI against experimental data from rat infarcts. B) Validation of predicted collagen accumulation (area fraction) post-MI from the tissue-level model. Experimental data were digitized from [37, 51].Model predictions are shown for the default model which has a uniform paracrine input peak height, along with an ensemble of 500 simulations in which the paracrine peak heights were randomly varied.