Figure 3: Simplified paracrine stimuli that mimic distinct phases of the post-MI fibroblast phenotype.

A) Principal component analysis (PCA) to visualize the fibroblast phenotype at specific times post-MI (red circles) or at steady state with 45 static paracrine conditions (representative singles in dark blue, pairs in light blue). B) PCA node loadings show the contribution of each node towards the overall predicted fibroblast phenotype in the first two principal components. C) Activity profile of fibroblast phenotype nodes at selected timepoints from dynamic post-MI simulations (left), or at steady-state with the best matching single (center) or paired (right) paracrine stimuli.