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. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Matrix Biol. 2020 Mar 21;91-92:136–151. doi: 10.1016/j.matbio.2020.03.007

Figure 6: Mechanisms contributing to context-dependent regulators of collagen expression post-MI.

Figure 6:

Overexpression or knockdown were simulated by increasing or decreasing the normalized expression parameter (ymax) for Smad7 (panel A), PKG (B), NOX (C), IL1 (D). The resulting post-MI dynamics of that node’s activity, collagen mRNA expression, and collagen area fraction are shown. Simplified schematics indicate the network mechanisms by which these nodes regulate collagen expression.