Fig. 2.

Rates (%) and timing of select AEs in patients with HCC receiving cabozantinib during the CELESTIAL trial. The size of the circle is proportional to the AE rate. AEs are color coded by system: blue: gastrointestinal; purple: skin and subcutaneous tissue; green: constitutional; orange: hepatic disorders; red: cardiovascular/hematological disorders; black: general/other. AE adverse event, ATE arterial thrombotic event, GI gastrointestinal, GR grade, HCC hepatocellular carcinoma, PPE palmar-plantar erythrodysesthesia, VTE venous thrombotic event