Table 5.

Supportive care resources for management of AEs relevant to patients with HCC receiving cabozantinib

Resources for HCPs
Oncology Nursing Society (ONS)
Putting Evidence into Practice (PEP) https://www.ons.org/the-pep-topics Evidence-based interventions for patient care
Fatigue Depression Anorexia Chemotherapy-induced diarrhea	Chemotherapy-induced nausea and vomiting Mucositis Skin reactions
National Comprehensive Cancer Network (NCCN)
Guidelines for supportive care https://www.nccn.org/professionals/physician_gls/default.aspx#supportive Evidence-based with consensus of expert panel
Cancer-related fatigue Distress management	Antiemesis
Cancer Care Ontario
Managing symptoms, side effects, and well-being https://www.cancercareontario.ca/en/symptom-management Evidence-based with consensus of expert panel and external review
Anxiety Depression Exercise Fatigue Sleep disturbances Constipation	Diarrhea Loss of appetite Nausea and vomiting Oral care (mouth care) Hand-foot syndrome Symptom assessment tools
European Society of Medical Oncology (ESMO)
ESMO clinical practice guidelines: Supportive and palliative care https://www.esmo.org/Guidelines/Supportive-and-Palliative-Care Evidence-based recommendations for the best standards of cancer care
Diagnosis, assessment, and management of constipation in advanced cancer Diarrhea in adult cancer patients Multinational Association of Supportive Care in Cancer (MASCC) and ESMO consensus guidelines for the prevention of chemotherapy- and radiotherapy-induced nausea and vomiting Management of oral and gastrointestinal mucosal injury Cardiovascular toxicity induced by chemotherapy, targeted agents, and radiotherapy
American Society of Clinical Oncology (ASCO)
Supportive care and treatment-related issues https://www.asco.org/research-guidelines/quality-guidelines/guidelines/supportive-care-and-treatment-related-issues%20 Systematic review of the medical literature by an expert panel
Antiemetics Practical assessment and management of vulnerabilities in older patients receiving chemotherapy
Hematology/Oncology Pharmacy Association (HOPA)
Guidelines, standards, and summaries http://www.hoparx.org/resources/guidelines-standards-summaries Resources for pharmacists to optimize patient care, including summaries of HOPA-recommended resources, and evidence-based guidelines with consensus of expert panel
2018 HOPA best practices for the management of oral oncolytic therapy: Pharmacy practice standard Oral chemotherapy resources
Multinational Association of Supportive Care in Cancer (MASCC)
MASCC guidelines https://www.mascc.org/guidelines Evidence-based with consensus of expert panel MASCC/International Society of Oral Oncology (ISOO) clinical practice guidelines for the management of mucositis secondary to cancer therapy MASCC/ESMO antiemetic guidelines MASCC endothelial growth factor receptor (EGFR) inhibitor skin toxicity tool
ONS/Association of Community Cancer Centers (ACCC)/HOPA/National Community Oncology Dispensing Association (NCODA)
Oral Chemotherapy Education www.oralchemoedsheets.com Printable, patient-oriented information about oral chemotherapy drugs and side effects, reviewed and updated quarterly

AEs are color coded by system: gastrointestinal; skin and subcutaneous tissue; constitutional; hepatic disorders; cardiovascular/hematological disorders; general/other

AE adverse event, HCC hepatocellular carcinoma, HCP healthcare provider