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. 2020 Jun 14;8(8):e1349. doi: 10.1002/mgg3.1349

FIGURE 4.

FIGURE 4

SNHG4 sponges miR‐377‐3p in osteosarcoma. (a) Bioinformatics analysis for predicting miR‐377‐3p binding sites in SNHG4. (b) Luciferase reporter assays using HOS and MG63 cells co‐transfected with the miR‐377‐3p mimic and SNHG4‐WT or SNHG4‐MUT reporter plasmid. (c) Significant increase of miR‐377‐3p levels in HOS and MG63 cells by SNHG4 downregulation based on the qRT‐PCR analysis. (d) qRT‐PCR for the determination of miR‐377‐3p expression in osteosarcoma tissues and para‐carcinoma tissues. (e) Negative association between SNHG4 and miR‐377‐3p expression in osteosarcoma tissues. All the data are from three individual experiments and shown as mean ± SD. **p < .01 and ***p < .001