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. 2020 Aug 18;10:13944. doi: 10.1038/s41598-020-70669-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Urinary LAM is present at detectable concentrations in extrapulmonary adult TB patients and in microbiologically confirmed pediatric TB patients. (A) Levels of urinary LAM as measured using MoAb1 are significantly higher in extrapulmonary patients with respect to pulmonary patients. (B) MoAb1 is superior in discriminating extrapulmonary patients from non TB controls. (C) Levels of urinary LAM measured using CS35 are lower in TB positive pediatric patients than in TB positive adults. (D) ROC analysis demonstrated that MoAb1 was superior to the other antibodies in discriminating pediatric TB patients from negative controls.