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. 2020 Aug 8;11(8):653. doi: 10.1038/s41419-020-02846-7

Fig. 4. LXA4 attenuates IR-induced pulmonary fibrosis and rescues lung function.

Fig. 4

a Representative gross (top), H&E (middle), and MT (bottom) images of the left lung tissue 6 weeks after 75 Gy IR with or without LXA4 in the mouse model. Magnification, ×40. b Quantification of inflammatory foci (left) and collagen content (right). c Quantification of relative α-SMA, Twist, IL-6, and TGF-β expression in the lung lesion site using immunohistochemistry. d Functional measurement of several mouse lung parameters using the flexiVentTM system 6 weeks post-IR, i.e., inspiratory capacity (IC), quasi-static compliance (Cst), central airway resistance (Rn), and airway construction (Rrs). Data are expressed as the mean ± standard error (n = 3‒5, *p < 0.05, **p < 0.01, and ***p < 0.001).