Fig. 7. LXA₄ decreases the IR-induced oxidative response.

a Representative image (right) and quantification (left) of irradiated lung tissues stained with antibodies against 8-OHdG at the indicated times. Magnification, ×1.25 and ×40. b Quantification of relative 8-OHdG and NOX4 expression in the lung lesion site 6 weeks after 75 Gy IR with or without LXA₄ using immunohistochemistry. c ROS levels were measured by incubating irradiated MLE12 cells treated with or without LXA₄ with a DCFDA probe. d MMP3, MMP8, and MMP12 mRNA expression in IR-exposed mouse lung tissue, measured using quantitative real-time PCR. e Colony forming activity was examined in MLE12 cells. Data are expressed as the mean ± standard error (n = 3, *p < 0.05, **p < 0.01, and ***p < 0.001).