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. 2020 Jun 12;123(4):673–688. doi: 10.1038/s41416-020-0928-1

Table 1.

Characteristic of studies included in the meta-analysis.

First author Study design Country Ethnicity (%) US method Comparison Number of patients Age (years)a Cancer detection rate (per 1000 screened) Added cancer detection rate (per 1000 screened) Number of patients with confirmed cancer
Patients with dense breasts
Wilczek et al.49 Retro Sweden Not specified ABUS (Rg) M alone 1668 49.5 ± 7.9 4.2 2.4 11
(Rg) M + US 1668 6.6
Brem et al.34 Pro USA

White 11915 (77.8)

Hispanics, Latinas or Spanish 810 (5.3)

American Indians or Alaskan natives 33 (0.2)

Asians 657 (4.3)

Blacks, African Americans or Haitians only 1645 (10.7)

Native Hawaiians or Pacific Islanders 27 (0.2)

Mixed race or ethnicity 108 (0.7)

Unknown or other race or ethnicity 123 (0.8)

 ABUS M alone 15,318 53.3 ± 10.0 5.4 1.9 82
(T) M + US 7.3 112
Giger et al.40b Retro USA Not specified ABUS M alone 185 N/A N/A N/A 52
(R) M + US 185 N/A N/A
Giuliano42 Pro USA Not specified ABUS M alone 4076 Median 54c 4.6 7.7 19
(T) M + US 3418 Median 57c 12.3 42
Korpraphong et al.47 Retro Thailand Not specified HHUS (R) M alone 14,483 Mean 49.4 6.5 1.4 115
M + US 7.9
Chae et al.36 Retro Korea Asian HHUS (R) M alone 12,505 Mean = 52 (range 22–91) 0.48 2.391 11
M + US 8359 2.871 24
Berg et al.30 RCT USA

White 2467 (92.8)

Hispanic or Latino 265 (10.0)

Black or African American 91 (3.4)

Native Hawaiian or other Pacific Islander 4 (0.2)

Asian 90 (3.4)

American Indian or Alaskan Native 4 (0.2)

Unknown 11 (0.4)

 HHUS (P) M alone 2659 55.2 ± 10.1 7.5 5.3 N/A
M + US 12.8
Kelly et al.3 Pro USA

White 3843 (87)

Hispanics 248 (6)

Asians 128 (3)

Blacks 61 (1)

 ABUS (T) M alone 6425 Median = 53 (range, 24–89) 3.6 3.6 57
M + US 6425 7.2
Patients with negative mammogram and dense breasts
Destounis et al.39 Retro USA Not specified HHUS M (–) → US 4898 Mean 55.8 3.3 N/A 18
Klevos et al.46 Retro USA Not specified HHUS (T followed by a radiologist) M (–) → US 394 NA N/A N/A 0
Kim et al.45 Pro Korea Asian HHUS (R) M (–) → US

Total: 3,171

Initial US: 998

Non-initial US: 2173

 51.2 ± 7.7

Total: 2.8

Initial US: 4

Non-initial US: 2.3

 N/A

Total: 9

Initial US: 4

Non-initial US: 5
Weigert33 Retro USA Not specified

HHUS

(T, in some substances, radiologist-rescanned)

 M (–) → US

Year 1: 2706

Year 2: 3351

Year 3: 4128

Year 4:

3331

 Range 45–77

Year 1: 4.1

Year 2: 2.7

Year 3: 2.7

Year 4: 3.0

 N/A

Year 1: 11

Year 2: 9

Year 3: 11

Year 4: 10
Chang et al.37 Retro Korea Asian HHUS (R) M (–) → US 990 Median = 47 (range, 27–79) 5.1 N/A 5
Girardi et al.41 Retro Italy Not specified HHUS (R) M (–) → US 9960 NA 2.21 N/A 22
Hooley et al.43 Retro USA Not specified HHUS (T) M (–) → US 935 52 (range, 29–86) 3.2 N/A 3
Leong et al.48 Pro Singapore

Chinese (94)

Indian (4)

Malay (1)

Eurasian (1)

 HHUS (S, radiologist verified) M (–) → US 141 Mean = 45.1 (range, 30–64) US: 14 N/A 2
Corsetti et al.28 Retro Italy Not specified HHUS M (–) → US 3356 N/A US: 4.4 N/A N/A
Youk et al.50 Retro Korea Asian HHUS (R) M (–) → US 1507 47.5 ± 7.8 29 N/A 43
Crystal et al.38 Retro Israel N/A HHUS (R) M (–) → US 1517 52.1 ± 8.1 4.6 N/A 7
Kaplan44 Pro USA Not specified HHUS (T or R) M (–) → US 1862 Range 35–87 3 N/A 6
Buchberger et al.35 Retro Austria Not specified HHUS (R) M (–) → US 8103 Mean 47.6 4.1 N/A 40

ABUS automated breast US, HHUS handheld US, M mammogram, N/A not available, Pro prospective study, Retro retrospective study, RCT randomised controlled trial, US ultrasound, USA United States of America, R radiologist-performed, Rg radiographer-performed, P physician-performed, S sonographer-performed, T technologist-performed.

aAge was summarised as mean ± standard deviation, or mean or median with range (minimum, maximum).

bEnriched-reader study.

cPatients with cancer.