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. 2020 Aug 18;11(8):642. doi: 10.1038/s41419-020-02903-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a, b The expression of EMT-related proteins and β-catenin were detected by western blotting in DNER knockdown or DNER-overexpressing cells with CHIR 99021 (6 μM, 24 h) or XAV-939 (4 μM, 24 h) treatment, respectively. c, d Cell growth was measured by CCK-8 in BC cells treated as described above. e, g Wound healing assay was used to examined migration ability in BC cells treated as described above. f, h Transwell assay showed the cell invasion abilities in BC cells treated as described above. Right: Quantitative analysis of invasion ratio was shown. The values are the mean ± SD from three independent experiments. *p < 0.05, **p < 0.01 vs the corresponding group.