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. 2020 Aug 12;10:1627. doi: 10.3389/fonc.2020.01627

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Copyright © 2020 Dong, Ding, Yu, Niu, Xue, Zhao, Xie, Song and Song.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Platelet-count dependent expression of U1, U2 and U5 was elevated by anticancer therapy. (A) TEP U1, U2, U5 expression was down-regulated in high platelet counts patients (n = 192) compared with that in low platelet counts patients (n = 189); (B) The platelet count levels were significantly lower in the post-therapy patients than in paired pre-therapy patients (n = 30); (C) The PDE levels were significantly lower in the post-therapy patients than in paired pre-therapy patients; *P < 0.05; **P < 0.005; ****P < 0.0001.