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. 2020 Aug 12;11:1213. doi: 10.3389/fphar.2020.01213

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Copyright © 2020 Niu, Lin, Luo, Zhu, Wei, Tang, Guo and Zhang

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Somatic mutations and their association with clinical characteristics in lung adenocarcinoma (LUAD). (A, B) The clinical characteristics and top 20 significantly mutated genes are shown for the NTRK3-MT and NTRK3-WT groups in the immune checkpoint inhibitor (ICI)–treatment cohort and the LUAD cohort from The Cancer Genome Atlas (TCGA). The frequencies of each gene in each cohort are displayed on the right. (C) Lollipop plot of neurotrophin tyrosine kinase receptor 3 (NTRK3) mutations in both the LUAD-MSKCC panel and the LUAD cohort from TCGA. (D) Status of NTRK3 copy number alterations (CNAs) in the LUAD cohort from TCGA, with gains shown in red and losses in blue.