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. 2020 Aug 12;10:1418. doi: 10.3389/fonc.2020.01418

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Copyright © 2020 Ren, Xu, Zhang, Chen, Zhang, Huang and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlation analysis of the progression of CRC and bacterial abundance. (A) Correlation analysis about bacterial microbiota and the progression of CRC based on duration after cholecystectomy, results of colonoscopy, complicating with preCA_CRC and the score of mucosal pathology. Spearman's correlation was performed. *p < 0.05. R 3.5.1 with the pheatmap package was used for data visualization. Abundance of (B) Bifidobacterium longum subsp. longum, (C) Veillonella dispar and (D) Megamonas funiformis in HC, non-CA and preCA_CRC groups, respectively. HC, healthy controls; non-CA, non-cancerous PC patients; preCA_CRC, PC patients with precancerous lesions and/or CRC.