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. 2020 Aug 12;8:724. doi: 10.3389/fcell.2020.00724

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Copyright © 2020 Wang, Ding, Lou and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of HDAC11 suppressed sorafenib resistance of HCC in vitro. (A) High expression of HDAC11 indicated poor prognosis in sorafenib-treated HCC from TCGA database. (B,C) HDAC11 mRNA and protein were significantly upregulated in SMMC7721/SR compared with SMMC7721. (D,E) HDAC11 expression was markedly decreased after treatment of siRNAs targeting HDAC11. (F,G) Inhibition of HDAC11 suppressed sorafenib resistance of SMMC7721. (H,I) Inhibition of HDAC11 suppressed sorafenib resistance of SMMC7721/SR. (J,K) Inhibition of HDAC11 attenuated colony formation of HCC cells. (L) GSEA suggested that drug metabolism cytochrome P450 pathway was significantly enriched in HDAC11-low expression group. *P < 0.05, **P < 0.01, ***P < 0.001.