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. 2020 Aug 18;10:13946. doi: 10.1038/s41598-020-70787-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Heterozygous KIF11 leads to alterations in cilia dynamics and length. (a) Asynchronously growing wild type (WT) RPE1 and heterozygous crKIF11 cells were fixed and probed with α-Arl13b (red), α-Cep135 (red), and the DNA was counter-stained with Hoechst (blue). Percentage of ciliated cells was calculated for each condition and graphed (n = 3 biological replicates for WT RPE1 and crKIF11-1 with 90–100 cells counted per n, n = 2 biological replicates for crKIF11-2 with 90–100 cells counted per n). Data analyzed by Student’s t-test. Error bars represent standard deviation. Median and quartiles denoted by dashed lines in violin plots. Representative images for each condition are shown in the image panels. (b) Cilium length was measured for each condition and graphed (n = 3 biological replicates with 20–30 cells counted per n). Data analyzed using a Student’s t-test. Error bars represent standard deviation. Representative images for each condition are shown in the image panels.