FIGURE 1.

SCID-Hu mice with thymus/liver xenografts were inoculated with VZV_LUC (firefly luciferase) and treated with vehicle or Comp 1 at 2.5 or 5 mg/kg in Cremaphor-DMSO-Saline s.c. daily from 2 h after infection to Day 7. Each mouse was weighed on the day before virus inoculation in order to calculate the drug concentration in the preparations. (A) Mice were injected with D-luciferin (150 mg/kg s.c.) and then VZV replication was measured by IVIS bioluminescence imaging daily from days 1–10. VZV yield was calculated as fold change for each mouse by dividing Total Flux values by the lowest value on Day 1. The lines are the average for the group (N = 7 Vehicle group, N = 8 treatment groups), the error bars are the standard deviation of the mean. Both doses of Comp 1 significantly reduced VZV yield compared to vehicle on Day 7 (p = 0.0037; 1-way ANOVA with Dunnett’s Multiple Comparison Test). (B) Mice were weighed on Day 10 and the net change for each mouse was calculated. Each symbol represents one mouse (some mice in the Vehicle group lost weight due aggressive activity). No mice died in any of the three groups.