FIGURE 1.

Molecular architecture of the T4ASS showing the location of the T4CP. Different components of the pilus, OMCC, IMC, and the ATPase energy center are shown. To show equivalence between VirB/VirD4 and R388 systems, proteins corresponding to R388 are shown in brackets. Arrows represent dynamic interactions of VirB11 protein through the conjugative process. VirD4 is highlighted in green. Red boxes highlight the proteins selected as targets for drug discovery (VirB8 and VirB11). OMCC, outer membrane core complex; IMC, inner membrane complex. The schematic representation is based on the structure described by Redzej et al. (2017). The image has been adapted from Waksman (2019).