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. 2020 Aug 12;11:992. doi: 10.3389/fphys.2020.00992

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Copyright © 2020 Brueggemann, Cribbs and Byron.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Summary of forskolin/IBMX and isoproterenol-induced increase in current amplitude of Q4–Q5 dimers, Q5–Q4 dimers, and Q5–Q4–Q5–Q4 tetramers, in comparison with M-currents through channels formed from co-expressed individual Kv7.4 and Kv7.5 α-subunits (Q4 + Q5). (A) Summarized bar graph of forskolin/IBMX (10 and 500 μM, respectively) -induced current enhancement through co-expressed individual Kv7.4 and Kv7.5 channels (Q4 + Q5, black, n = 5), Q4–Q5 dimer (red, n = 4), Q5–Q4 dimers (blue, n = 6), and Q5–Q4–Q5–Q4 tetramers (green, n = 6), measured at −20 mV. *Significant difference from co-expressed individual Kv7.4 and Kv7.5 channels (P = 0.002, One Way ANOVA). (B) Summarized bar graph of isoproterenol (1 μM)-induced current enhancement through co-expressed individual Kv7.4 and Kv7.5 channels (Q4 + Q5, black, n = 5), Q4–Q5 dimer (red, n = 4), Q5–Q4 dimers (blue, n = 4), and Q5–Q4–Q5–Q4 tetramer (green, n = 4), measured at −20 mV. *Significant difference from co-expressed individual Kv7.4 and Kv7.5 channels (P = 0.015, One Way ANOVA). Dashed lines indicate control current level.