Table 3.

Correlation of MTX plasma levels at 48 hours with toxicity markers.

Measurement (in plasma)	Spearman’s correlation coefficient	P-value
Creatinine level (t = 48 h)	0.187	0.000018
Creatinine level (t = week 1)	0.163	0.0000018
ALAT levels (t = 48 h)	0.102	0.03
ASAT levels (t = 48 h)	0.085	0.07
Hemoglobin levels (t = week 1)	-0.109	0.001
Thrombocyte counts (t = week 1)	-0.053	0.12
Leukocyte counts (t = week 1)	0.023	0.50
Neutrophil counts (t = week 1)	-0.033	0.38

Values depicted in bold are statistically significant (P-value < 0.05).