Table 4.
Characteristics of laboratory markers for liver damage and bone marrow toxicity, graded according to National Cancer Institute Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0.
| CTCAE term | Case-control designation | Cases, n of measurements (%) | Controls, n of measurements (%) |
|---|---|---|---|
| Alanine aminotransferase increased | CTCAE grade 0–1 vs. grade 2–4 | 358 (75.4) | 177 (24.6) |
| Aspartate aminotransferase increased | CTCAE grade 0–1 vs. grade 2–4 | 237 (51.4) | 224 (48.6) |
| Anemia | CTCAE grade 0–1 vs. grade 2–5 | 293 (32.3) | 615 (67.7) |
| Platelet count decreased | CTCAE grade 0 vs. grade 1–4 | 351 (39.2) | 545 (60.8) |
| White blood cell decreased | CTCAE grade 0–1 vs. grade 2–4 | 194 (21.4) | 711 (78.6) |
| Neutrophil count decreased | CTCAE grade 0–2 vs. grade 3–4 | 87 (12.3) | 622 (87.7) |