Table 5.
Genetic variants with a statistically significantly associated result (p < 9.2 × 10-5) in analysis with continuous outcomes, and corresponding results from analyses with binary outcomes.
| Outcome | Gene | Variant | Chr | Position | Minor allele | MAF | Linear multivariate GEE analyses with continuous outcome | Logistic multivariate GEE analyses with binary outcome (CTCAE) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Coef | 95% CI | P | Coef | 95% CI | P | |||||||||
| MTX plasma levels | SULT1E1 | rs3736599 | 4 | 70,725,821 | A | 0.08 | -0.31 | -0.46 | -0.17 | 0.00003 | n.a. | n.a. | n.a. | n.a. |
| Thrombocyte counts | CYP2B6 | rs4803418 | 19 | 41,511,803 | G | 0.31 | -0.19 | -0.27 | -0.10 | 0.00003 | 0.32 | 0.01 | 0.63 | 0.046 |
| Thrombocyte counts | CYP4F8 | rs4808326 | 19 | 15,726,147 | A | 0.10 | 0.19 | 0.10 | 0.29 | 0.00006 | -0.97 | -1.55 | -0.39 | 0.001 |
| Thrombocyte counts | CYP2B6 | rs4803419 | 19 | 41,512,792 | T | 0.32 | -0.19 | -0.28 | -0.09 | 0.00009 | 0.32 | 0.00 | 0.65 | 0.051 |
MAF, minor allele frequency; GEE, generalized estimated equations; CTCAE, common terminology criteria of adverse events; MTX, methotrexate; Coef, coefficient; CI, confidence interval; P, p-value; n.a., not applicable.