TABLE 1.

Primary antigens targeted in CAR-T therapy for pediatric brain tumors.

Antigen	Tumor expression	Function	References
EGFRVIII	Glioblastoma, Ependymoma, Medulloblastoma	Brain development and is associated with tumor development and progression	(186, 187)
HER-2	Glioblastoma, Ependymoma, Medulloblastoma, metastatic tumors	Cell cycle homeostasis	(49, 54, 132)
B7-H3	Diffuse Midline gliomas, medulloblastoma, and most pediatric solid tumors	Potent immune inhibitory functions	(53, 136)
GD2	Primarily Diffuse Midline Gliomas, neuroblastoma, melanoma	Attachment of tumor cells to extracellular matrix proteins	(138, 188)
IL13RA 2	High-grade glioma, Ependymoma, Medulloblastoma	Apoptosis escape mechanism	(54, 189, 190)
EPHA2	Gliomas, Ependymoma, Medulloblastoma	Enhances tumorigenesis, tumor cell migration and invasion, angiogenesis, and metastasis	(54, 191, 192)
SURVIVIN	Ependymoma, glioma	Apoptosis inhibitor protein	(142)
PRAME	Medulloblastoma	Inhibits retinoic acid signaling	(47)
CD 70	Glioma	Tumor necrosis factor receptor family	(130)
PDPN	Carcinoma, sarcoma, seminoma, brain tumors	Transmembrane glycoprotein	(151)