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. 2020 Aug 12;10:1261. doi: 10.3389/fonc.2020.01261

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Copyright © 2020 Xing, Tian, Zhang, Guo, Tang, Wang, Lv and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Both the high-content screening (A) and MTT (B) experiments showed that after the overexpression of SNAIL protein, the A375 cell proliferation rate was increased in the KD+OE group compared to the KD+NC group. (C) Compared with the KD+NC group, the caspase-3/7 activity of apoptotic A375 cells was decreased in the KD+OE group. (D) SNAIL was found to be downregulated in the shDDX39A group compared to the shCtrl group. *P < 0.05, **P < 0.01, ***P < 0.001. All analyses shown in this figure were calculated from three distinct experiments.