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. 2020 Aug 12;10:1261. doi: 10.3389/fonc.2020.01261

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Copyright © 2020 Xing, Tian, Zhang, Guo, Tang, Wang, Lv and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transwell migration experiments (A,C) showed that the numbers of cells detected in the lower chamber in the NC+NC group, KD+NC group, and KD+OE group were 109 ± 7.22, 40 ± 1.60, and 91 ± 0.39, respectively, indicating that the migration of DDX39-knockdown melanoma cells can be promoted by SNAIL overexpression. Transwell invasion experiments (B,C) showed that the numbers of cells that moved to the lower chamber in the NC+NC group, KD+NC group, and KD+OE group were 113 ± 3.56, 30 ± 5.41, and 106 ± 3.46, respectively, indicating that the invasion of DDX39-knockdown melanoma cells can be activated by SNAIL overexpression. Magnification, 100×. ***P < 0.001. The mean and standard deviation (SD) values of at least three repeated experiments are reported.