Figure 1.

Effect of B2BrBC and C66 on hyperoxia‐induced airway hyperreactivity in rat pups. (a) In hyperoxic group of animals (n = 8) contractile responses were greater than in normoxic group (n = 8) (p < .001). In the presence of B2BrBC (100 μg/ml) or C66 (100 μg/ml) contractile responses of hyperoxic TSM were lower than those recorded in absence of these compounds. (b) In the normoxic group neither B2BrBC nor C66 had any effect on contractile responses of TSM. *Hyperoxia versus Normoxia; ^#Hyperoxia + B2BrBC versus Hyperoxia control; ^§Hyperoxia + C66 versus Hyperoxia control. **p < .01; ***p < .001; ^## p < .01; ^§ p < .05. Data represent mean ± SEM of eight experiments for each condition