Figure 2.

Effect of B2BrBC and C66 on hyperoxia impaired EFS‐induced relaxation of the TSM of rat pups. (a) In hyperoxia‐exposed group of animals (n = 6) EFS‐induced relaxation of TSM was reduced as compared to those obtained from normoxia‐exposed group (n = 6). In the presence of B2BrBC (100 μg/ml) relaxant responses of hyperoxic TSM were restored and significantly higher than those recorded in absence of this compound (p < .001), while the presence of C66 (100 μg/ml) did not have any significant effect on EFS‐induced relaxant responses of TSM. (b) B2BrBC or C66 did not have any effect on EFS‐induced relaxation of TSM in normoxic group. *Hyp eroxia versus Normoxia; ^#Hyperoxia + B2BrBC versus Hyperoxia control; ^§Normoxia control versus Hyperoxia + B2BrBC; ^†Normoxia control versus Hyperoxia + C66. *p < .05; ***p < .001; ^### p < .001; ^§§§ p < .001; ^††† p < .001. Data represent mean ± SEM of six experiments for each condition