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. 2020 Aug 12;11:2039. doi: 10.3389/fimmu.2020.02039

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Copyright © 2020 Lin, Zhang and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Correlations of the MANTIS score and immune-related characteristics. Correlation of the MANTIS score and TMB in the ICI-treated CRC cohort (A). Correlations of the MANTIS score and tumor immunogenicity (B), immune cells (C), the immune score (D), an APP-related gene (E), a CYT-related gene (F), and an ICP-related (G) gene in the TCGA-CRC cohort. CRC, colorectal cancer; TCGA, The Cancer Genome Atlas; TMB, tumor mutational burden; MSS/MSI-L, microsatellite-stable/microsatellite instability-low; MSI-H, microsatellite instability-high; IFN, interferon; CYT, cytolytic activity; APP, antigen processing and presentation; and ICP, immune checkpoint.