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. 2020 Aug 12;11:2039. doi: 10.3389/fimmu.2020.02039

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Copyright © 2020 Lin, Zhang and Luo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Possible mechanism underlying the difference in the efficacy of ICI treatment in CRC patients with different MSI statuses. (B) The high expression of immune checkpoints in the GEP of MSI-H CRC indicates targets for ICIs.