Table 5.
Complications noted in various Indian studies on pediatric scrub typhusa
| Complications | Kumar et al. (Puducherry)4 | Bhat et al. (Dehradun)6 | Palanivel et al. (Chennai)5 | Kalal et al. (Bengaluru)8 | Narayanasamy et al. (Puducherry)9 | Masand et al. (Jaipur)10 | Krishna et al. (Chennai)7 | Ganesh et al. (Chennai)12 | Present study (Chandigarh) |
|---|---|---|---|---|---|---|---|---|---|
| Year | 2010–2011 | 2011–2012 | 2010–2011 | 2010–2012 | 2014–2015 | 2013 | 2010–2011 | 2012–2015 | 2013–2015 |
| Number of patients | 35 | 66 | 67 | 53 | 117 | 30 | 52 | 358 | 160 |
| Age range | 1.5–12 years | 8 months–18 years | <12 years | <18 years | 6 months–12 years | 3–16 years | 7 months–16 years | <18 years | 3 months–12 years |
| Design | Prospective | Prospective | Prospective | Prospective | Prospective | Retrospective | Retrospective | Prospective | Retrospective |
| Cardiac dysfunction/myocarditis | 34% | 9.1% | 24% | 0.5% | 3% | ||||
| Hepatitis | 31% | 13.6% | 64.17% | 81.1% | 8% | 60% | 62% | ||
| ALF | 10.4% | 4% | |||||||
| Thrombocytopenia (<1.5 lakh/mm3) | 61% | 27.2% (<50,000) | 77.6% (<1 lakh) | 66.7% | 41% | 26% (<1 lakh) | 25% (<1 lakh) | 23.2% (<1 lakh) | 82.5% |
| AKI | 20% | 16.7% | 10.4% | 12% | 3.3% | 10% | 16% | ||
| Meningoencephalitis | 6% | 30.3% | 5.97% | 17% | 8% | 7.7% | 1.9% | 29% | |
| Pneumonia | 3% | 10.6% | 14.9% | 16% | |||||
| Respiratory failure/ARDS | 9% | 12.1% | 4.47% | 8% | 6.6% | 3% | 11% | ||
| DIC | 9% | 1.5% | 1.5% | 0.2% | 13% | ||||
| Shock | 25.8% | 44.7% | 10% | 46% | 3.8% | 3.9% | 17% | ||
| Mortality | 2.8% | 7.5% | 11.9% | 0 | 6.6% | 0 | 0.8% | 8.8% |
ALF, acute liver failure; AKI, acute kidney injury; ARDS, acute respiratory distress syndrome; DIC, disseminated intravascular coagulation
a
Published between 2011 and 2018 and a minimum of 30 cases