Table 2. Cox proportional hazards regression analysis and log-rank test analysis for pretreatment high HbA1c (NGSP) group (≥5.5) and clinicopathological factors for overall survival.

Variables		Univariate p valuea	Multivariate analysis
			HRb	95% CIc	p valued
Gender	Male	0.06	1.58	0.70–3.56	0.27
	Female
Tumor depth	T3T4	<0.01	1.44	0.74–2.80	0.28
	T1T2
Nodal status	positive	<0.01	5.33	2.51–11.31	<0.01
	negative
Distant metastasis	positive	<0.01	3.09	0.88–10.81	0.08
	negative
CRP	≥0.2	0.03	0.94	0.53–1.67	0.83
	<0.2
ALB	<4.1	0.12	1.30	0.69–2.46	0.42
	≥4.1
BMI	<18.5	0.28	1.40	0.71–2.80	0.33
	≥18.5
Hemoglobin	< 11.6	0.27	1.56	0.63–3.86	0.34
	≥ 11.6
HbA1c	<5.5	0.04	1.94	0.76–4.97	0.17
	≥5.5

BMI: body mass index; CRP: C-reactive protein; HbA1c: hemoglobin A1c

^aLog-rank test analysis

^bAdjusted hazards ratio

^cAdjusted 95% confidence interval

^dCox proportional hazards regression analysis