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. 2020 May 26;123(4):624–632. doi: 10.1038/s41416-020-0913-8

Fig. 1. Females live longer than males in a metastatic model of CRC, and survival is correlated with increased CD8 T cells in the TME.

Fig. 1

105 MC38 cells were delivered intraperitoneally to syngeneic male and female mice. a Females had increased survival, and b a higher percentage of CD8+ T cells in the TIL population, as assessed by FCA. c IHC staining with anti-CD8 confirmed greater infiltration of CD8 + cells in females. d Mice were divided by CD8+ infiltration, as assessed by FCA, into high (above mean) and low (below mean) groups. High infiltration correlated with survival (n = 5–10). *p < 0.050, **p < 0.010.