Fig. 3. Human mAb 93k forms a stable interface with gB Domain IV.

a–d Location in the 2.8-Å cryo-EM map (top left panels) of the extracted densities (top right panels; scenes captured from Supplementary Movie 3) for the gB protomer and the associated bound 93k Fab. The densities of gB DIV (orange), 93k VH chain (blue) and 93k VL chain (light blue) are highlighted. A ribbon diagram and side chains of the amino acids at the extracted densities are shown with those highlighted in green representing the interactions formed at the gB-93k interface. The bottom panels duplicate the regions in the top right panels but without the extracted cryo-EM map densities. The β23, β25-26, β29-30, and the NH₂ terminus of gB are highlighted with orange boxes, and the VHCDR1, VHCDR3, VLCDR1, and VLCDR2 are highlighted by blue boxes; VH – dark blue, VL – light blue.